Recently Published Editions: No. 4 - 1997

Symposium Metabolism and Action of Thyroid Hormone Special Issue Dedicated to G. Hennemann Edited by T.J. Visser, Ph. D and E.P. Krenning, M.D., Rotterdam, The Netherlands Preface Cellular Uptake of Thyroid Hormone Author References An Update on Thyroxine Activation in Humans Common features of the iodothyronine deiodinases Author Acknowledgements Efforts to Understand the Molecular Basis of Thyroid Hormone-Regulated Brain Development The model Demonstration of nuclear T3 receptors in rat brain Cloning of the thyroid hormone receptor cDNA Current concepts of thyroid hormone action Application of molecular techniques to the study of thyroid hormone-dependent brain development Receptor isoform-specific TR levels during early postnatal brain development Search for T3-responsive brain genes Three potential mechanisms to explain the time course of gene expression Does raising the level of thyroid hormone in the fetus by itself accelerate gene expression? Is TRb1 required for thyroid hormone-initiated gene expression of target genes? Do other developmentally regulated factors determine thyroid hormone responsivity? Clinical implications Summary Author Acknowledgments, References Clinical Relevance of Thyroid Hormone Alterations in Nonthyroidal Illness Diagnosing hypothyroidism and hyperthyroidism Therapeutic implications Author References The Epidemiology of Thyroid Diseases Thyrotoxicosis Chronic autoimmune thyroiditis Hypothyroidism Sporadic goitre Screening for thyroid disease Author References "Subclinical" Thyroidology Working Point of the Pituitary-Thyroid axis Setpoint of the Pituitary-Thyroid Axis Changes of the Setpoint Working Point and Setpoint of George Hennemann Author References