| We have already pointed out the coordinated rise in total T3 and T3 receptor in the immediate postnatal period and have raised the question as to whether these changes by themselves could account for the structural and biochemical changes observed in brain during this period. Our observations raise a number of fundamental issues. What is the receptor isoform composition of the receptor during this period? Does the response of specific genes depend on the level of specific receptor isoforms? Does the rise in T3 cause the rise in receptor level? We therefore initiated a series of studies to examine these issues. |
