References
 
  1. Weetman AP. Hypothyroidism: screening and subclinical thyroid disease. Brit Med J 1997; 314: 1175- 1178.


  2. Nystrom E, Caidahl K, Fager G, Wikkells” C, Lundberg PA, Lindstedt G. A double-blind cross-over 12-month study of L-thyroxine treatment of women with 'subclinical' hypothyroidism. Clin Endocrinol 1988; 29: 63-76.


  3. Cooper OS, Halpern R, Wood LC, Levin AA, Ridgway EC. L-thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial. Ann Int Med 1984; 101: 18-24.


  4. Monzani F, Del Guerra P, Caraccio N et al. Subclinical hypothyroidism: neurobehavioral features and beneficial effect of L-thyroxine treatment. Clin Invest 1993; 71: 367-371.


  5. Tanis BC, Westerndorp RGJ, Smelt AHM. Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a re-analysis of intervention studies. Clin Endocrinol 1996; 44: 643-649.


  6. Uzzan B, Campos J, Cucherat M, Nony P, Boissel JP, Perret GY. Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis. J Clin Endocrinol Metab 1996; 81: 4278-4289.


  7. Ching GW, Franklyn JA, Stallard TJ, Daykin J, Sheppard MC, Gammage MD. Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis. Heart 1996; 75: 363-368.


  8. Sawin CT, Geller A, Wolff PA et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. New Engl J Med 1994; 331: 1249-1252.


  9. Nagayama I, Yamamoto K, Saito K, Kuzuya T, Sato T. Subject-based reference values in thyroid function tests. Endocrine J 1993; 40: 557-562.


  10. Fish LH, Schwartz HL, Cavanaugh J, Steffes MW, Bantle JP, Oppenheimer JH. Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. New Engl J Med 1987; 316: 764-770.


  11. Spencer CA, LoPresti JS, Guttler RB, Eigen AC, Shen D, Nicoloff JT. Applications of a new chemilurminescent thyrotropin assay to subnormal measurements. J Clin Endocrinol Metab 1990; 70: 453-460.


  12. Meier CA, Maisey MN, Lowry A, Muller J, Smith MA. Interindividual differences in the pituitary- thyroid axis influence the interpretation of thyroid function tests. Clin Endocrinol 1993; 39: 101-107.


  13. Mariotti S, Franceschi C, Cossarizza A, Pinchera A. The aging thyroid. Endocrine Rev 1995; 16: 686- 715.


  14. Kennedy RL, Jones TH, Cuckle HS. Down's syndrome and the thyroid. Clin Endocrinol 1992; 471- 476.


  15. Fliers, Guldenaar SEF, Wiersinga WM, Swaab DF. Thyrotropin-releasing hormone gene expression in the human hypothalamus in relation to nonthyroidal illness. Program 79th annual meeting of the Endocrine Society, Minneapolis, 1997, 129 (abstract # OR-44-3).


  16. Roux N de, Misrahi M, Brauner R et al. Four families with loss of function mutations of the thyrotropin receptor. J Clin Endocrinol Metab 1996; 81: 4229-4235.


  17. Prummel MF, Bakker O, Wiersinga WM. TSH-receptor mRNA is present in the human pituitary. Program 10th International Congress of Endocrinology, San Francisco, 1996; 403 (abstract #P1-1073). Table. Course of thyroid function tests in the transition from the euthyroid to the hypothyroid or hyperthyroid state.