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There were several studies related to iodine deficiency. Ivanova et al., Sofia, Bulgaria, published results of 51 pregnant women with regard to thyroid status who were included in a iodine supplementation program (20 mg KIO3/kg salt). They concluded that during pregnancy this program appeared not to be sufficient to compensate for the increased requirements during pregnancy. Fadeyev et al., Moscow, Russian Federation analyzed the prevalence of thyroid disorders in 215 pregnant women living in an area of mild iodine deficiency . They concluded that in mild iodine deficiency pregnancy is a risk factor for goiter and that the presence of thyroid auto-antibodies is not a risk factor for thyroid dysfunction or spontaneous abortion Comment: these two latter conclusions are at variance with the literature, see Muller et al. www.hotthyroidology.com. Heydarian et al., Tehran, Islamic Republic of Iran, looked for autoimmune thyroid disorders 10 years after implementation of iodine prophylaxis in 1,434 subjects > 20 years of age. They especially stressed the association of TPO-Ab and an elevated TSH. Shakhtarin et al., Obninsk, Tver, and Bryansk, Russian Federation, report administration of iodine tablets to groups of children from three different iodine deficient areas and report a decrease in anti-Tg and anti-TPO but not so much in serum TSH and FT4. Tsyb et al., Obninsk, Russian Federation, and Arynchyn et al., Minsk, Belarus, and Obninsk, Russian Federation, both report a positive effect of the use of bread enriched with iodcasein on the iodine status in children living in an area of iodine deficiency. Mazziotti et al., Naples, Italy, studied the effects of post operative administration of T4 only versus T4 plus iodine in patients operated for non-toxic goiter living in an area of moderate iodine deficiency. They found that when apart from T4, iodine is also administered in the form of iodized salt, the post-operative thyroid remnant remains smaller than in the patients treated with T4 only. This effect was independent from TSH levels. |
