| Country |
Year(s) of the survey(s) |
Design, patients and methods |
Findings |
References |
|
| Belgium |
1998 |
National survey
Thyroid volume by ultrasound (criteria: Delange et al. 199755) and UI
in 2,855 SAC aged 6–12y from 23 sites. |
TGR: 5.7 % (18.4 % in girls aged 12 y).
Median UI: 80 µg/l
< 100 µg/l: 67 %
< 50 µg/l: 19 %
Homogeneous. No gradient. |
Delange et al. 199756
Delange et al. 200023 |
|
| Bosnia-Herzegovina |
1999 |
National survey
Prevalence of goiter (palpation) and UI in 5,523 SAC aged 7–14 y from all cantons |
TGR:12.9 %–51.2 %
Global UI <100 µg/l: 70 %
< 50 µg/l: 34 % |
Tahirovic et al. 200157 |
|
| Bulgaria |
1998–2001 |
National survey: TGR and UI in 9,045 SAC aged
7–11 y. |
TGR: <5–28 % (Total 13 %)
Median UI: 88–165 µg/l
National: 111 µg/l |
Ivanova et al. 200058
Lozanov 200159 |
|
| Croatia |
1995 |
National survey. TGR (palpation) and UI in
2,856 SAC. |
TGR: 11–35 %
Median UI: < 100 µg/l: 66–91 %
< 50 µg/l: 14–52 % |
Kusic et al. 199660 |
|
|
1996 |
National survey: TGR and UI in 2,054 SAC aged
7–11 y. |
TGR: 5–18 % (Mean: 15 %)
Median UI: < 100 µg/l: 30–59 %
< 50 µg/l: 5–22 % |
Antonic et al. 200061 |
|
|
2002 |
Thyroid volume (US using the adapted Delange et al.
criteria13) and UI in 540 SAC from four regional centers |
Thyroid volume within the normal range
Median UI: 131–147 µg/l
< 100 µg/l: 24.7–32.8 %
< 50 µg/l: 5.7–11.9 % |
Kusic Personal communication |
|
| Czech Republic |
2001 |
Thyroid volume (US) and UI in 467 randomly selected
persons aged 6–65y. |
Mean thyroid volume in adults:
15.7 ml
Mean UI in: adults: 140 µg/l
children: 168 µg/l
< 50 µg/l: 1.1 % |
Zamrazil, personal communication |
|
|
National survey
Thyroid volume (US) and UI in ± 5000 children (6–13y), adolescents (14–18y)
and adults (18–65y) |
Mean thyroid volume
Adults: 15.2 ± 7.4 (SD) ml
Children: 4.5 ± 2.2 (SD) ml
UI:
Adults: 114 ± 57 (SD) µg/l
Children: 136 ± 67 (SD) µg/l |
Zamrazil 200062 |
|
| Denmark |
1998–1999 |
Measurement of the iodine content of drinking water
from 55 locations |
Medians vary from <1 to 139 µg/l
National median: 41 µg/l
Correlation with 24-h UI measured in 1967 by Munkner64 |
Pedersen et al. 199963
Munkner 196964 |
|
|
1993–1999 |
TGR and UI measured in different locations and age groups |
TGR in 391 women aged 15–60y: 17 %.
Goiter stage II in 60-y old women: 3 %.
Thyroid enlargment in 13.1 % of females and 6.2 % of males.
Multinodular structure of the thyroid in 23 % of the population and
solitary cold nodules in 2.4 %.
Median UI vary from 38–110 µg/l Iodine intake stable over the last 30–40 years;
Median UI in neonates vary from 16 to 59 µg/l (National median: 32 µg/l) and are
correlated with the iodine content of breastmilk (22–55 µg/l). |
Nygaard et al. 199365
Knudsen et al. 200066
Knudsen et al. 199967
Nohr et al. 199468 |
|
|
? |
Thyroid volume, UI, serum TSH, T4, T3 Tg in 54
pregnant women and their neonates in east Jutland (UI:50 µg/L) |
Serum TSH and Tg increase during gestation and are
elevated on cord. Prevented by iodine supplementation. |
Pedersen et al. 199369 |
|
|
1996–1997 (?) |
Comparative epidemiological study of thyroid
abnormalities in the elderly in Iceland (median UI 150 µg/L) and in Jutland (median
UI 38 µg/L). n = 100 in Iceland ; 423 in Jutland. Mean age: 68 y. |
Serum TSH < 0.40 mU/l: 9.7 % in Jutland (range: < 0.01
to 0.40) ; 0 % in Iceland.
Serum TSH > 0.40 mU/l: 3.8 % in Jutland ; 18 % in Iceland. |
Laurberg et al. 199870 |
|
| France |
1999 |
National survey (SUVIMAX)
TGR by ultrasound (method not described) and UI in 7,154 women and 4,860 men aged
35–60 y. |
TGR: 13.9 % in women ; 11.3 % in men
National median UI: 85 µg/l
< 50 µg/l: 15–23 % |
Valeix et al. 199916 |
|
| Germany |
1993–1994 |
Thyroid volume determined by ultrasound and TGR in
5,932 individuals aged 1–89 y in 32 regions.
Goiter defined by thyroid volume above 18 ml in adult females and 25 ml in adult
males. |
TGR in adults 18–70 y: 49 % in women and 51 % in males
(NS)
Frequency of thyroid nodules: 30% in women and 21 % in men (P < 0.001)
Gradient North to South West to East |
Hampel et al. 199520 |
|
1994–1995 |
Measurement of iodine content of food, urines,
breastmilk and of thyroid volume by ultrasound in SAC |
Iodine intake of adults increased from 46–66 µg/day
to 99–139 µg/day.
Iodine content of breastmilk increased from 36 µg/l in 1990 to 95 µg/l in 1995.
UI in SAC reached 101 µg/g creat but TGR changed much less |
Meng and Schindler71 |
|
|
2000 (?) |
National survey
UI in 3,065 SAC aged 6–12 y from
128 sites |
National median UI:
148 µg/l
< 100 µg/l: 27 %
< 50 µg/l: 7 %
Homogeneous. No gradient |
Hampel et al.72 |
|
| Hungary |
1994–1997 |
National survey
TGR (palpation) and UI in 299,351 SAC aged 7–11 y. |
National TGR: 15 %
Median UI: 40–130 µg/l
(+ 1 site: 250 µg/l)
< 100 µg/l: 25–92 % |
WHO, Dept. of Nutrition for Health and Development
(NHD), personal communication |
|
| Italy |
1978–1991 |
National survey including 71,112 SAC aged 6–14 y.
Determination of the prevalence of goiter (palpation), UI and thyroid function. |
TGR: 4–60 %. Below 5 % in only one site in one
province.
Urinary I/creat. ratio varies from 10 to 122 µg/g and is below 100 in 12/16
provinces examined.
Serum TSH and T4: within the normal range except in endemic areas (Sicily,
Trentino Alto-Adige).
Serum Tg can be elevated in the absence of elevated TSH |
Pinchera et al. 199573 |
|
|
? |
Neonatal thyroid screening in Calabria (22,384
infants) |
Blood TSH > 5 mU/l in 14.4 % |
Costante et al. 199774 |
|
|
? |
Spectrum of thyroid disorders in Pescopagano (UI:
55 µg/l) |
TGR: 16 % in children ; 59.8 % in adults.
Thyroid nodularity: 0.5 % in children; 28.5 % in adults.
Prevalence of hyperthyroidism in adults: 2.9 %. |
Aghini-Lombardi et al. 199936 |
|
|
? |
Multicentre study on UIE in 1789 individuals from 28
centers (319 newborns and their mothers ; 223 infants aged 1–3 months ;
857 SAC aged 8–10 y). |
Median UI: Newborns: 73 µg/l
Mothers: 55 µg/l
Infants: 69 g/l
SAC: 122 µg/l
(< 50 µg/l in SAC: 14 %) |
Rapa et al. 199975 |
|
| Luxembourg |
1999 |
National survey UI in 495 SAC aged 12–14 y. |
National median:
77 µgI/g creat
<100 µgI/24h: 60 % |
Wagener and Hoffmann Personal communication |
|
|
2001 |
National survey
UI in 514 SAC aged 12–14 y. |
National median:
85 µgI/g creat. |
Wagener and Hoffmann
Personal communication |
|
| Macedonia |
1995–1996 |
National survey:
TGR (palpation + ultrasound) and UI in 11,486 SAC
aged 7–15 y from 115 schools in 30 clusters. |
TGR (n=11,486): 8–30 % (Mean:19%)
Median UI (n=2,380) 117 µg/L
< 100 µg/L: 26 %
< 50 µg/L: 0 % |
Karanfilski et al. 199876 |
|
|
2001 |
National survey:
TGR and UI in 929 SAC aged 8–10 y. in 30 clusters and in 490 pregnant and lactating
women |
National TGR: 5 %
Median UI: 165 µg/l
< 100 µg/l: 16 %
< 50 µg/l: 3 %
UI in pregnant and lactating women 140 µg/l
< 100 µg/l: 25 % |
Karanfilski. Personal communication |
|
| The Netherlands |
1995–1996 |
Thyroid volume by palpation and ultrasound (national
reference values) and UI in 937 SAC aged 6–18y in two study sites, one of them in
a formerly iodine deficient area. |
TGR by palpation: 0.8 % and 2.6 % respectively.
TGR by ultrasound: < 5 %
Median UI: 154 µg/l |
Wiersinga et al. 200177 |
|
| Poland |
1999 |
Thyroid volume by ultrasound (criteria Delange et al.
199755) and urinary iodine in 884 SAC aged 6–15 y from 12 primary schools in selected
areas based on previous endemicity established during a national survey in 1994. |
|
1994 |
1999 |
| TGR |
38.4 % |
7.0 % |
| UI (µg/l) mean |
60 |
96 |
| % < 100 |
87 % |
64 % |
|
Szybinski et al.49 |
|
| Romania |
1999–2002 |
National survey:
SAC aged 6–16 y: TGR in ± 50,000 from all 41 counties
UI in 7,509 from 30 counties |
SAC
TGR: 5.2–22.0 %
UI: > 100 µg/l: 6.3 %
< 50 µg/l: 28.7 %
(Barely unchanged as compared to survey in 1991–1992) |
Simescu and Sbranca Personal communications |
|
|
Pregnant women: UI in 1,066 samples from 12 counties |
Pregnant women
UI > 100 µg/l: 0 %
50–100 µg/l: 84.0 %
< 50 µg/l: 16.0 % |
|
|
| Slovakia |
1994 |
UI in 900 children and adolescents |
Median UI: 144 µg/l |
Podoba
Personal communications |
|
| Turkey |
1997–1999 |
National survey:
TGR (ultrasound, Delange et al. criteria (55)) and UI in 5,948 SAC aged 9–11 y from
20 city centers. |
TGR: 6–58 % (Mean: 32 %)
Median UI: 14–62 µg/l. |
Erdogan et al. 200252 |
TGR: Total Goiter Rate. UI: Urinary Iodine. SAC:
School-aged children. US: Ultrasound. NS: Non significant difference.
|