The Thyroid History of Merck KGaA, Darmstadt, Germany

1894 Thyroidinum siccatum Introduction of desiccated sheep thyroid gland (powder, later tablets) in Germany 1896 Thyroidin Merck (USA) Offered in the price list published in Merck's 1896 Index (New York) 1901 Antithyroidin Merck Produced from the serum of thyrectomized rams (Moebius) 1912 Research on a standardized thyroid extract product (Annual report Scientific Laboratory 1912) 1925 Evaluation of Kendall's Thyroxine "Obviously thyroxine is not the only active thyroid product" 1928 Novothyral Introduction of water soluble standardized thyroid extract (Axolotl) 1932 Thyroidea Opton Introduction of protein-free degradation product of the thyroid gland 1941 Thyroidin Merck Standardized also with Axolotl method 1968 Novothyral Newly introduced as a T3/T4 combination in Germany 1973 Euthyrox Mono T4 tablets introduced in Germany, later in many other countries 1975 Jodid Merck KI 100 mcg tablets (later 200 and 500 mcg) introduced in Germany 1979 Kalium jodatum Compretten (100 mg KI) Indicated for prevention of radioactive iodine incorporporation in nuclear accidents 1985 Jodthyrox T4/Iodide combination introduced in Germany for iodine deficiency goiter 1997 Euthyrox Introduced by EM Pharma in the USA, the world's largest thyroid market