Thyrozol
 

Posology and method of administration

Depending on the degree of severity of the hyperthyroidism the initial dose is 20 - 40 mg thiamazole/day for a period of 3 - 6 weeks. After this the dose can be reduced to a maintenance dose of 20 to 10 - 5 mg thiamazole/day. From this point on concomitant therapy with thyroid hormone is recommended.

Alternative:

Monotherapy with 2.5 - 10 mg thiamazole/day.

In pregnancy:

Thiamazole should be given in as low a dose as possible, e.g. 2.5 - 10 mg thiamazole/day without concomitant therapy with thyroid hormones.

Preoperative administration:

20 - 40 mg thiamazole/day until the hyperthyroidism has been eliminated. To shorten the period of time before surgery is performed Thyrozol 5 can be given in combination with a beta-blocker and/or iodine preparation.

Radioiodine therapy:

Before radioiodine therapy: 20 - 40 mg thiamazole/day.
After radioiodine therapy: 20 - 10 to 5 mg thiamazole/day depending on the symptoms up to onset of the radioiodine effect.

Antithyroid maintenance therapy:

2.5 - 10 mg thiamazole/day with or without the addition of a low levothyroxine dose.

Prophylactic treatment in latent hyperthyroidism before exposure to iodine:

20 - 40 mg thiamazole/day in combination with levothyroxine.

Ingestion: the tablets should be swallowed whole after meals, preferably with a little liquid.
The daily dose can be divided up into 2 - 3 single doses or it can be administered in one dose. Therapy is usually given over a period of 6 months to 2 years.
In preoperative preparation Thyrozol is given up to the time of the operation.
When used in preparation for radioiodine therapy Thyrozol is given up to about 7 days before the administration of radioiodine and is continued 10 days after the therapy for a further period of 2 - 4 months as intermediate therapy up to the onset of the effect of the radioiodine therapy.
In prophylactic treatment prior to exposure to iodine the duration depends on the retention time of the iodine-containing substance in the organism.


Contraindications

Known hypersensitivity to thiamazole or thionamides. Previous bone marrow damage after carbimazole or thiamazole is an absolute contra-indication.
Earlier allergic skin reactions to thionamides constitute a relative contra-indication. Large goiters which constrict the trachea should only be treated with thiamazole for a short period (in combination with levothyroxine).