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Thyroid hormone is
essential for normal bone turnover. Excessive thyroid hormone
levels, either of endogenous origin or by thyroid hormone
replacement, resulting in TSH-suppression, leads to bone loss.
The latter appears partially reversible after adequate treatment,
yet an increased risk for osteoporosis may persist. Therefore, it
appears prudent to assess bone mineral density in subjects with
thyrotoxicosis and subjects on hormone replacement therapy with
suppressed TSH. Bisphosphonates and estrogen replacement therapy
may prevent the detrimental effects of excessive thyroid hormone
on bone.
Hypothyroidism itself seems to have little (clinically significant) effect on the skeleton. |
