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Clinical questions requiring further investigation
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Which, if any, free T4 and free T3 methods reflect
circulating hormone levels in nonthyroidal disorders without concurrent
hypothyroidism or hyperthyroidism?
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Is the "set-point" for the hypothalamic-pituitary-thyroid axis altered
in nonthyroidal illnesses? Do available in vitro assays for TSH and free
T4 allow us to assess this axis?
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How can changes in serum thyroid hormone levels in sick patients without
hypothalamic, pituitary or thyroid disease be distinguished from those
with concurrent hypothyroidism or hyperthyroidism?
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Should thyroid hormone therapy be given to sick patients without hypothyroidism?
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